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Unable to Connect Hardware Wallet on MyEtherWallet

Please try the following. This solves 99% of problems.

  • Restart your computer (Do not be lazy. Restart it FIRST).
  • Use Google Chrome.
  • Make sure you don't have any other apps that connect to your Ledger open (e.g. the Ledger Bitcoin Chrome app, Mist, etc.)
  • Make sure you have contract data turned ON. (This option is found under the Ethereum section on the Ledger Nano S device itself)
  • That you are confirming any transactions via your Ledger.
  • Try a different USB cable

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